Partnering

Uniting therapeutic innovation
with global capabilities

To realize the full potential of DARPin® therapeutics for patients, we believe strong external collaborations are an essential component of our success. Building on the multiple advancements we achieved and lessons learned from years of developing the DARPin® drug class, we aim to collaborate with partners that share our drive and commitment to speed the discovery and development of breakthrough therapies for patients. Depending on the field, the DARPin® asset, the medical problem, the potential partner’s needs and the collaboration set-up, we customize the deal structure and strive for fast and nimble decision-making during the process from idea generation through to partnership.

To date, Molecular Partners has received combined upfront and milestone payments of approximately CHF 300 million in connection with its agreements with its partners. The company is further eligible to potentially receive additional success-based payments, including up to approximately CHF 1.00 billion in aggregate development, regulatory and sales milestones, and tiered royalties for future product sales.

In 2020, we entered into a collaboration with Novartis to develop, manufacture and commercialize the DARPin® candidates MP0420 and MP0423, which are potential medicines with a unique approach for both the prevention and treatment of COVID-19, with the possibility to manufacture at scale, easy administration and with the potential to bypass cold storage.

Under the agreement, during the option period, we will conduct Phase 1 clinical trials for MP0420 and perform all remaining preclinical work for MP0423 and Novartis will conduct Phase 2 and Phase 3 clinical trials, with Molecular Partners as sponsor of these trials. Upon option exercise, Novartis would be responsible for all further development and commercialization activities. During the clinical development stage, we will provide clinical supply. The companies will work together to scale-up manufacturing capacity, in collaboration with Sandoz, the generics and biosimilar Novartis division, to provide worldwide supply.

In 2018, we entered into a collaboration and license agreement with Amgen for the clinical development and commercialization of AMG 506 (MP0310). AMG 506 (MP0310) is a preclinical molecule designed to locally activate immune cells in the tumor by binding to fibroblast-associated protein, or FAP (a localizing target) on tumor stromal cells and co-stimulating T cells via 4-1BB (an immune modulatory protein).

Under the terms of the agreement, Amgen obtains exclusive global development and commercial rights for AMG 506 (MP0310). The parties will jointly evaluate AMG 506 (MP0310) in combination with Amgen’s oncology pipeline products, including its investigational BiTE®(bispecific T cell engager) molecules. Under the collaboration, we retains certain rights to develop and commercialize its proprietary DARPin pipeline products in combination with AMG 506 (MP0310).

AbbVie and Molecular Partners have an ongoing discovery alliance focused on the selected multi-DARPin® for use in ophthalmology through AbbVie’s subsidiary, Allergan. In 2018, Allergan exercised the last of its three options upon which we granted Allergan an exclusive license to the selected multi-DARPin® product candidates.